Duke Blue Devils 2010 Final Four Odds, Picks & Predictions: The Duke Blue Devils are hoping to reverse their recent Sweet 16 luck on Friday when they meet the Purdue Boilermakers at Reliant Stadium in Houston, Texas. Oddsmakers at BetUS.com like the Dukies chances of doing just that as they presently have Mike Krzyzewski's squad listed as a -145 moneyline favorite to win the South Region in their Duke Blue Devils 2010 Final Four Odds, Picks & Predictions.
Duke has not fared well in the Sweet 16 over the last decade, going 1-6 in the Regional Semifinals since 2000. The Blue Devils 
latest setback in the round of 16 came last year against Villanova as they lost to the Wildcats 54-77 as a two seed. However, this year's team appears to be the best all-around group since the Duke team that lost to Connecticut in the National Semifinal in 2004. At least their play in the first two rounds would indicate that.
The Blue Devils shot a respectable 49 percent in their wins over Arkansas-Pine Bluff and California, but their offense has not been the biggest attention grabber. Duke's defense held the Lions and Bears to an average of 48.5 points per game while limiting the two teams to a combined 35.5 percent field goal shooting.
The manner in which the Blue Devils won their first two tournament games (average 22 point margin of victory), combined with the fact that they have recorded wins in 14 of their last 15 games, has many believing in Coach K's team again. The legendary Krzyzewski can be counted among those, but he is not willing to put the cart before the horse.
"It's not a great team, but it's a really — it's an excellent defensive team that hopefully can be a little bit better offensively as we go forward," Krzyzewski said.
BetUS.com Duke Blue Devils 2010 Final Four Odds, Picks & Predictions:
To Win South Region -145
To Reach Final +225
To Win National Championship +450
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