Notre Dame vs Purdue College Football Predictions, College Football Odds & College Football Picks: The Purdue Boilermakers welcome the Notre Dame Fighting Irish to Ross-Ade Stadium tonight as the two schools ready for their annual dust up. The Boilermakers will look to rebound from a stunning home loss to Northern Illinois while the Irish vie for a 3-1 record and a possible move back into the rankings. Kickoff is set for 8:00pm ET in West Lafayette, Indiana; the game will be televised live on ESPN. College Football Predictions at Bodog.com have the Purdue listed as a +7 against the spread home underdog.
Notre Dame narrowly avoided an 1-2 start as they just got by the Michigan State Spartans 33-30 in South Bend last 
weekend. Irish safety Kyle McCarthy picked off Spartans quarterback Kirk Cousins late in the fourth quarter with Michigan State inside the Notre Dame 20 yard line. The interception helped preserve a win in which Charlie Weis' squad gave up 27 first downs and 459 yards.
Jimmy Clausen and the Notre Dame offense dinged up the Spartan defense too, though, racking up 25 first downs and 437 yards. Clausen, who injured his toe in the win, completed 22-of-31 passes for 300 yards and two touchdowns. The junior passer, who has yet to throw an interception this season, connected with wide receiver Golden Tate seven times for 127 yards and a score.
Purdue had a 7-0 lead after a quarter of play last week, but Northern Illinois took control of the game with 21 second quarter points. The outburst propelled the Huskies to a 28-21 win and left the Boilermakers with a 1-2 record on the season. UNI finished the game with 454 total yards, 23 first downs, and a 23 minute time of possession advantage.
The Boliermakers had three fumbles, which prevented them from getting into an offensive rhythm and, consequently, assured their demise. Quarterback Joey Elliott had pedestrian numbers, completing 20-of-31 passes for 188 yards, but running back Ralph Bolden continued his stellar play. The sophomore, who has 421 rush yards and four touchdowns this year, had 12 carries for 64 yards and four receptions for 62.
College Football Predictions Betting Trend: The Fighting Irish are 0-4 against the spread and 1-3 straight up over the last five seasons when playing as a road team coming off a game in which they scored between 29 and 35 points.
Notre Dame vs Purdue College Football Predictions, Odds & Picks:
Notre Dame Fighting Irish -7 (-105), Over 60 (-105), -255 (Moneyline)
Purdue Boilermakers +7 (-115), Under 60 (-115), +215 (Moneyline)
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