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The No. 16 Oklahoma State Cowboys will host the Missouri Tigers in a crucial BIG 12 Conference game at Boone Pickens Stadium in Stillwater Okla., with kickoff set for 8:15 pm on ESPN2.

Missouri leads the all-time series with the Cowboys, 28-21. Missouri leads the series by a 5-2 count during the Big 12 era. The road team has won the last four games in the series (two each in Stillwater and Columbia). In Stillwater, the all-time series is even at 11-11 with Missouri riding a four-game winning streak in its last four visits to Stillwater.

College football picks oddsmakers at online sportsbook SBGglobal.com lists Oklahoma State as 6 1/2-chalk ATS and -250 moneyline favorite versus Mizzou with a 55-total. Tigers backers are getting +210 odds on the SBG Global moneyline.

Missouri was defeated 27-12 by Nebraska in Week 6, as 4-point underdogs. That game's combined score went UNDER the posted total of 50. Blaine Gabbert ran for the lone Missouri TD in that loss.

Zac Robinson threw two touchdown passes and Oklahoma State overcame the absence of their top two playmakers to beat Texas A&M 36-31 in Week 6. The Cowboys just missed covering the 5.5-point spread, while the final score played OVER the day's posted total of 58.5.

College Football Picks: Take OSU -6.

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