NFL Picks San Francisco 49ers vs. Arizona Cardinals NFL Betting Odds: The Arizona Cardinals will defend their NFC West title in front of their hometown faithful when they host division rival San Francisco at 4:15 PM ET. Last year the Cardinals went undefeated against their division rivals but motivating 49ers head coach Mike Singletary will have his charges fired up to break that streak. The Cardinals are looking to get back to the Superbowl after narrowly losing to Pittsburgh last season.
The 49ers will try to get on the winning side of the board after 6 consecutive losing seasons. The NFL Picks experts at online sportsbook Bodog.com have opened the home team at -7 point favorites but NFL bettors took notice of the 49ers stellar preseason and have knocked the number down to the Arizona Cardinals -6 points against the San Francisco 49ers.
San Francisco 49ers Offense vs. Arizona Cardinals Defense: The 49ers offense revolves around stud running back Frank Gore and he has a great track record against the Cardinals. In the passing game the Cardinals should have the upper hand with a strong pass-rush and playmakers in the secondary in Adrian Wilson and Antrel Rolle. 49ers QB Shaun Hill is a quality leader with nice accuracy and pocket presence but he does not have the arm-strength or playmakers to hurt Arizona.
The Free NFL Picks experts at online sportsbook Bodog.com have the NFL betting odds on the 49ers vs Cardinals Total set at 46 points.
Arizona Cardinals Offense vs. San Francisco 49ers Defense: The Cardinals pass the ball as much as any team in the NFL and have the games best WR in Larry Fitzgerald . Arizona QB Kurt Warner is still an elite player that can fit the ball in tight spots when given time. The 49ers pass-rush is below-average and it will be up to playmaking LB Patrick Willis and CB Nate Clements to create turnovers. The Cardinals have a nice 1-2 punch on the ground this season with power backs Beanie Wells and Tim Hightower. Wells and Hightower will be tested by a solid 49ers run defense that is led by the All-Pro Willis.
Intangibles: The 49ers will have a huge advantage on special teams over Arizona. 49ers starting safety Michael Lewis is listed as probable with a head injury. Arizona star WR Anquan Boldin is listed as questionable with a hamstring injury and his status should be monitored closely. San Francisco has went a money burning 2-6-1 ATS in their last 9 against the NFC.
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