Indianapolis Colts vs Arizona Cardinals NFL Odds, NFL Predictions & NFL Picks: The Colts will be on the primetime stage again as they take on the Arizona Cardinals in Phoenix on NBC's Sunday Night Football. Indy improved to 2-0 on Monday night with a dramatic win at Miami. The Cardinals are coming off their own road win after beating the Jaguars in Jacksonville. This evening's game is set to kickoff at 8:20pm ET at the University of Phoenix Stadium. NFL Odds at Sportsbook.com have Arizona listed as a -3 against the spread favorite.
Colts Breakdown: If your opponent is dead set on grinding a game out and punishing your defense with a smash mouth, 
clock eating rushing attack, then you had better be able to move the ball quickly. Peyton Manning and the Colts did just that on Monday night and they earned a 27-23 win at the expense of the Dolphins as a result. Miami held the ball for 45:07 and racked up 239 rush yards (403 total) and 27 first downs in the process, but even that was not enough to secure victory.
Indianapolis made the most of its 14:53 time of possession, producing 356 yards and 27 points. That is a staggering 24.5 yards and 1.8 points per minute. Manning led the impressive assault with a 303 yard, two touchdown outing. He hooked up with tight end Dallas Clark seven times for 183 yards and a score and he threw a game winning 48 yard touchdown pass to Pierre Garcon with 03:18 left in regulation.
Cardinals Breakdown: Arizona shook off its preseason and week one funk last Sunday, smoking the Jaguars 31-17 in Jacksonville. The Cardinals had 383 yards of offense in the win as quarterback Kurt Warner completed 24-of-26 passes for 243 yards and two touchdowns. Warner's 92.3 completion percentage set an NFL record for pass efficiency in a single game.
The Cardinals defense sacked Jags quarterback David Garrard four times and they picked him off once. Arizona's swarming defense also forced two Jacksonville fumbles, which neutralized the 372 yards they gave up to Jack Del Rio's squad.
NFL Odds Betting Trend: The Colts are 2-0 against the spread and straight up as a road dog with a spread between 0 to 3.3 and a total between 47.5 and 51. The Colts are 8-1 straight up over the last five years playing as an away team coming off a road win.
Sportsbook.com Indianapolis Colts vs Arizona Cardinals NFL Odds, Predictions & Picks:
Indianapolis Colts +3 (-115), Over 48.5 (-110), +130 (Moneyline)
Arizona Cardinals -3 (-105), Under 48.5 (-110), -150 (Moneyline)
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