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Indianapolis Colts vs Tennessee Titans NFL Picks, NFL Odds & NFL Predictions: It has been do or die time for the Titans the past two weeks, but now it is for real. If 0-4 is NFL purgatory, then 0-5 might as well be eternal damnation. Unfortunately for Jeff Fisher's team, they will have to stave off the flames of oblivion against one of the best teams and, arguably, the best quarterback in the league. Indianapolis, in stark contrast to their AFC South rival, will be gunning for a perfect 5-0 mark when things kickoff at 8:20pm ET tonight at LP Field in Nashville (NBC). NFL Picks at Sportsbetting.com have Indy listed as a -4 against the spread road favorite. 

Colts Breakdown: Indianapolis stormed its way to an easy 34-17 win over the Seahawks last Sunday, bringing its record to 4-0 and further solidifying its lead in the AFC South. Quarterback Peyton Manning, who has been the best player in the league this season, turned in another outstanding performance. The former MVP completed 31-of-41 passes for 353 yards and two touchdowns. The offense finished the game with 24 first downs, eight third down conversions (13 attempts), and 431 total yards.

Indy's defense, other than giving up two late touchdowns to the Seahawks, played nearly flawless football as well. Seattle managed just 279 yards for the game and quarterback Seneca Wallace got sacked five times by the Dwight Freeney-less Colts defense.

Titans Breakdown: Tennessee looked like a hard luck team inits first three losses of the season, but last week they looked a like team that was mentally defeated. The Jaguars offense abused the Titans D in almost every possible way, racking up 442 yards and 27 first downs in a lopsided 37-17 win. Tennessee's offense picked up 19 first downs and a respectable 379 yards, but it could not overcome signal caller Kerry Collins' mistake prone play. The veteran quarterback threw for 284 yards, but he also tossed a pair of costly interceptions.

The loss buried the Titans in the AFC South cellar, making tonight's contest less about record and more about pride.

NFL Picks Betting Trend: Tennessee is 1-9 straight up in their last 10 games as a home underdog with a spread between 4 and 7.5. The Colts are 9-1 straight up as a road favorite with a spread between 4 and 7.5.

Sportsbetting.com Indianapolis Colts vs Tennessee Titans NFL Picks, Odds & Predictions:

Indianapolis Colts -4 (-115), Over 45 (-110), -200 (Moneyline)

Tennessee Titans +4 (-105), Under 45 (-110), +170 (Moneyline)

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