Indianapolis Colts vs St. Louis Rams NFL Odds, NFL Picks & NFL Predictions: The Indianapolis Colts are coming off a bye this week, and fortunately for Peyton Manning and company, they get the equivalent of another today as they face the winless Rams at the Edward Jones Dome in St. Louis. The game is scheduled to get underway at 1:00pm ET on CBS. NFL Odds at Bodog.com have the Colts listed as a -14.5 against the spread road favorite.
Colts Breakdown: Indy headed into their bye week with a perfect 5-0 record, beating Jacksonville, Miami, Arizona, Seattle, 
and Tennessee by an average of 13.2 points per game. The Colts are also an impressive 4-1 against the spread (3-0 on the road) after averaging 27.4 points per game and allowing a meager 14.2 (29.7 and 14 on the road). The Peyton Manning led offense is posting 404.8 yards per outing (third in the league behind New Orleans and Dallas) while the defense is giving up 295.6 yards per contest.
Rams Breakdown: St. Louis fell to 0-6 last weekend, losing 20-23 at Jacksonville in overtime. It was just the second time this season the Rams flirted with victory, the other being a 7-9 loss at Washington. Not surprisingly, St. Louis has been a great fade play, going just 2-4 against the spread after averaging 9.2 points and giving up 28.2 per game. The Rams are generating just 281.3 yards per contest while giving up 384.5. They are also 0-2 against the spread at home where they have scored an average of 13.5 points outing while allowing a staggering 37.
NFL Odds Betting Trend: Any team playing as a road favorite coming off a bye week and facing a non-conference is 9-3 against the spread and 10-2 straight up over the last five season. Take the Colts -14.5.
Bodog.com Indianapolis Colts vs St. Louis Rams NFL Odds, Picks & Predictions:
Indianapolis Colts -14.5 (-105), Over 45 (-110)
St. Louis Rams +14.5 (-115), Under 45 (-110)
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