San Francisco 49ers vs Indianapolis Colts NFL Predictions, NFL Picks & NFL Odds: The Indianapolis Colts look to make it seven in a row today as they host the San Francisco 49ers at Lucas Oil Stadium. The Niners, however, will be desperate for a win having dropped their last two ball games. The game is set to kickoff at 1:00pm ET on FOX. NFL Predictions at Sportsbetting.com have the Colts listed as a -13.5 against the spread home favorite.
Forty Niners Breakdown: San Francisco got its season started with a bang, going 3-1 and taking control in the NFC West. However, things have taken a turn for the worse over the last few weeks with the Niners dropping back-to-back games. Their record is now evened up at 3-3 and they are in second place in the division looking up at the defending NFC Champion Cardinals. San Francisco has had trouble moving the ball and slowing down their opposition the last two games, that does not bode well for a squad facing a point a minute Colts squad.
Colts Breakdown: The league might as well hand the AFC South trophy to Indy right now because Peyton Manning and company all but have the title secured. The Texans are in the picture, but they are two games back of the 6-0 Colts and it does not appear that Indy will be slowing down anytime soon. The team is averaging over 29 points per game while giving up just 12.8, and they have the best player in the league running the show on offense. That said, Indy is about to go through its roughest stretch of the year, facing Houston twice, Baltimore, New England, and Denver over the next six weeks.
NFL Predictions Betting Trend: The Over is 8-2 in the Colts last 10 games as a home favorite with a total between 44.5 and 47.
San Francisco 49ers +13.5 (-105), Over 45 (-110), +550 (Moneyline)
Indianapolis Colts -13.5 (-115), Under 45 (-110), -750 (Moneyline)
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