Indianapolis Colts vs New England Patriots 2010 NFL Picks, Predictions & Odds

Indianapolis Colts vs New England Patriots 2010 NFL Picks, 2010 NFL Predictions & 2010 NFL Odds: One of football's biggest rivalries when enjoy its latest installment this afternoon as the Patriots host the Colts at Gillette Stadium in Foxborough, Massachusetts. The huge, nationally televised game is scheduled to get underway at 4:15pm ET on CBS. 2010 NFL Picks, Predictions & Odds at online bookmaker have the Patriots listed as a -4 against the spread home favorite and the game total set at 50.

The banged up Colts come into this game with a 6-3 overall record and a first place position in the tightly contested AFC Indianapolis Colts vs New England Patriots 2010 Picks, Predictions & OddsSouth. Since getting off to a 2-2 start, Peyton Manning and company have won four of their last five games, including last Sunday's 23-17 victory over the Bengals at Lucas Oil Stadium. 

Manning, who was operating without offensive weapons Austin Collie, Dallas Clark, Anthony Gonzalez, and Joseph Addai, failed to throw a touchdown pass as Indy struggled through 256 yard day. Five turnovers on the part of Cincinnati helped the injury plagued Colts escape their fourth loss of the season.

New England improved to 7-2 last weekend with a 39-26 road win at Pittsburgh. The win the sixth in the last seven games for the Patriots, which own a share of the AFC East lead with the New York Jets.

New England, which managed just 283 total yards in a week nine 34-14 loss at Cleveland, lit the Steelers defense up for 453 yards and 26 first downs. Tom Brady, who was not sacked by the Steelers, completed 30-of-43 passes for 350 yards and three touchdowns in the win.

The Patriots, which are 4-0 at home this season, certainly got the better of this rivalry in the early 2000's, winning four in a row over Indy (including the playoffs) from 2003 to 2005. However, the series has been decidely in the Colts favor the last five years with Indianapolis winning five of the last six meetings between the two AFC stalwarts.

NFL Picks Betting Trend: The Colts are 7-3 against the spread (6-4 straight up) in their last 10 games as a road dog in the month of November.

Football Spreads Indianapolis Colts vs New England Patriots 2010 NFL Picks, Predictions & Odds:

Indianapolis Colts +4 (-105), Over 50 (-105)

New England Patriots -4 (-115), Under 50 (-115)

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