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Indianapolis Colts vs Houston Texans NFL Odds, NFL Picks & NFL Predictions: The Indianapolis Colts are set to take on AFC South rival Houston this afternoon in what has become a critical game for the Texans. Kickoff in this division clash is set for 1:00pm ET at Reliant Stadium in Houston; the game will be broadcast live on CBS. NFL Odds at online bookmaker Sportsbook.com have the Colts listed as a -3.5 against the spread road favorite.

Colts Breakdown: Indianapolis ran its record to a perfect 10-0 last Sunday with another close win. This time the Colts dispatched a game Ravens squad 17-15 in Baltimore giving them their fifth road win of the season. While many consider Indy to be the best team in the league, things have definitely not come easy for Peyton Manning and company over the last several weeks. The 17 point margin of victory average that the team enjoyed over the first six weeks of the season has been a mere 2.5 per contest over the last four games.

Texans Breakdown: Houston had a severe dent put in its playoff hopes on Monday night as the Tennessee Titans came into Reliant Stadium and handed the Texans a 17-20 defeat. The loss marked the squad's second consecutive 17-20 setback (lost 17-20 at Indianapolis on November 8th) and brought their record to an even 5-5. The Texans can ill afford a loss to the Colts this afternoon with Jacksonville, Pittsburgh, and Denver all sitting ahead of them in the AFC playoff standings. However, that may be exactly what they get given that they are just 1-6 against Indy at home.

Sportsbook.com Indianapolis Colts vs Houston Texans NFL Odds, Picks & Predictions:

Indianapolis Colts -3.5 (+100), Over 47.5 (-110), -170 (Moneyline)

Houston Texans +3.5 (-120), Under 47.5 (-110), +150 (Monyeline)

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