The San Francisco 49ers have traveled cross country to square off against the Buffalo Bills at 1:00pm ET at Ralph Wilson Stadium. Mike Singletary's squad when be looking for a better result than their last trip to New York, a 17-29 loss to the Giants back in October. NFL Picks at SBGglobal.com have the Bills listed as a -6.5 home favorite.
49ers Breakdown: San Francisco, at 3-8, is in second place in the lackluster NFC West. A 2-3 mark in division play has lifted them above the lowly Rams and Seahawks, but still has them four games back of the Cardinals. Last week the 49ers were blasted 35-22 by the Cowboys in Dallas. The San Francisco defense has had difficulty keeping opposing teams out of the end zone, as their 28.2 points per game allowed average would indicate.
Bills Breakdown: Buffalo started the season on fire, but most recently they have had to claw their way above the .500 mark. They currently possess a 6-5 record and a last place position in the AFC East standings. Last Sunday they ended a four game losing skid by pounding the Chiefs 54-31 at Arrowhead. The Bills are averaging 24.8 points per game after their effort in Kansas City on Sunday.
NFL Picks Betting Trend: The 49ers are 2-8 straight up in their last 10 games as a road dog in the month of November.
SBGglobal.com's NFL Picks: San Francisco 49ers vs Buffalo Bills
49ers +6.5 (-110), Over 42.5 (-110), +240 (Money line)
Bills-6.5 (-110), Under 42.5 (-110), -280 (Money line)
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