USF vs. Pitt College Football Picks: The 20th ranked Pitt Panthers face a serious challenge to their unblemished conference mark when they play BIG EAST challengers University of South Florida Bulls at Heinz Field in Pittsburgh on Saturday (12:00 PM ET). For USF, this game will be the second major challenge in as many weeks as the Bulls lost a showdown with No. 5 Cincinnati in Tampa last week. 
College Football Picks oddsmakers at Sportsbook.com like the home team in this one having Pitt installed as -6 1/2 ATS and -240 moneyline favorites with a 48.5 total. Bulls backers are getting +200 moneyline odds as a road underdog.
South Florida was defeated 34-17 by Cincinnati last time out, as 2.5-point underdogs. The 51 points made it OVER the posted total of 49. B.J. Daniels threw for 208 yards with a TD while rushing for another score in that losing effort.
Pittsburgh built up an early lead and went on to defeat Rutgers 24-17 in Week 7. Pittsburgh covered the 6.5-point spread, while the 41 points went UNDER the posted total of 46. Dion Lewis carried the ball 31 times for 180 yards with two touchdowns in that win for the Panthers.
College Football Picks: We like Pitt SU but advise taking USF ATS (6 1/2).
